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Subclinical left ventricular dysfunction is associated with reduced brain structure and function.

Park, Chloe, Williams, Emily, Tillin, Therese, Stuart, Robert, Chaturvedi, Nish and Hughes, Alun (2015) Subclinical left ventricular dysfunction is associated with reduced brain structure and function. In: 2015 Annual Scientific Meeting of the BHS, 21-23 Sep 2015, Stratford-upon-Avon, UK.

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Background: Subclinical left ventricle (LV) dysfunction has been associated with early cognitive impairment; however findings are inconsistent. We investigated the association between LV function and both functional and structural measures of thebrain. Methods: A community-based sample 1207 individuals (69±6 yrs) underwent echocardiography and cognitive function assessment using the Community Screening Instrument for Dementia score (CSID).Hippocampal volume was measured by MRI. Fast-ing bloods including NT-pro BNP levels were measured. Measures of LV systolic and diastolic function included peak shortening velocity in systole (s’), and LA diameter (indexed to height2.7(LADI)). Results: After adjusting for age, sex and ethnicity, hippocampal volume was associated with all measures of LV function (Table 1: Model 1). CSID was significantly associated with diastolic but not systolic function. After further adjusting for diabetes, stroke, education and hypertension all significant associations remained (Table 1: Model 2). Conclusion: In a community-based sample of older people, measures of LV function were associated with functional and structural measures of cognitive impairment. These associations were not explained by concomitant risk factors.

Item Type: Conference or Workshop Item (Conference Paper)
Divisions : Faculty of Health and Medical Sciences > School of Health Sciences
Authors :
Park, Chloe
Tillin, Therese
Stuart, Robert
Chaturvedi, Nish
Hughes, Alun
Date : October 2015
DOI : 10.1038/jhh.2015.90
Copyright Disclaimer : © 2015 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.
Related URLs :
Additional Information : Session: Young Investigators Awards Session Clinical Science.
Depositing User : Clive Harris
Date Deposited : 12 Jul 2017 12:52
Last Modified : 19 Jun 2018 14:41

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