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Risk of cardiovascular disease: impact of Type 2 diabetes and socioeconomic disadvantage by ethnic group

Williams, Emily, Tillin, T, Hughes, AD and Chaturvedi, N Risk of cardiovascular disease: impact of Type 2 diabetes and socioeconomic disadvantage by ethnic group In: Diabetes UK Professional Conference 2015, 2015-03-11 - 2015-03-13, ExCeL London, UK.

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Objectives: Low socioeconomic position (SEP) and Type 2 diabetes are cardiovascular disease (CVD) risk factors; however, whether they interact to increase CVD risk further is unknown. SEP, diabetes and CVD vary across ethnic groups; it is important to understand how these relationships differ across groups. Methods: Longitudinal data were collected from 2,028 White European and 1,475 South Asian adults from a community based cohort study in northwest London. At baseline (1989), manual occupation defined low SEP and Type 2 diabetes was determined based on participant/GP record. Fatal/non-fatal CVD events were assessed at 20-year follow-up using participant/GP/hospital records. Results: Of those with diabetes, 61% of low and 62% of high SEP Europeans and 75% of low and 56% of high SEP South Asians had experienced a CVD event by follow-up. Among South Asians, in age-, sex- and baseline CVD-adjusted Cox regression models, there was a significant diabetes–SEP interaction (p=0.021); low SEP South Asians with diabetes had nearly double the CVD risk of their high SEP counterparts [hazard ratio (HR) 1.80, 95% confidence interval 1.15–2.82) (in South Asians without diabetes, SEP was not associated with CVD, HR 1.05, 0.86–1.28). In contrast, in Europeans, the risk of CVD did not differ between high and low SEP individuals, with or without diabetes (HR 1.15, 0.58–2.27 and HR 1.17, 0.99–1.39, respectively). Conclusions: This study demonstrates that the combination of diabetes and socioeconomic disadvantage is associated with higher CVD risk in South Asian people. Among South Asians with Type 2 diabetes, socioeconomic adversity may be important in the identification of individuals at increased risk of CVD.

Item Type: Conference or Workshop Item (Conference Poster)
Divisions : Faculty of Health and Medical Sciences > School of Health Sciences
Authors :
Tillin, T
Hughes, AD
Chaturvedi, N
DOI : 10.1111/dme.12668
Copyright Disclaimer : © 2015 The Authors, presented at the Diabetes UK Professional Conference © 2015 Diabetes UK.
Additional Information : Published in Diabetic Medicine, Special Issue: Abstracts of the Diabetes UK Professional Conference 2015, ExCeL London, 11–13 March 2015. March 2015. Volume 32, Issue Supplement S1.
Depositing User : Clive Harris
Date Deposited : 12 Jul 2017 10:38
Last Modified : 16 Jan 2019 18:54

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