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Vaccinia virus evasion of regulated cell death

Veyer, David L, Carrara, Guia, Maluquer de Motes, Carlos and Smith, Geoffrey L (2017) Vaccinia virus evasion of regulated cell death Immunology Letters, 186. pp. 68-80.

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Regulated cell death is a powerful anti-viral mechanism capable of aborting the virus replicative cycle and alerting neighbouring cells to the threat of infection. The biological importance of regulated cell death is illustrated by the rich repertoire of host signalling cascades causing cell death and by the multiple strategies exhibited by viruses to block death signal transduction and preserve cell viability. Vaccinia virus (VACV), a poxvirus and the vaccine used to eradicate smallpox, encodes multiple proteins that interfere with apoptotic, necroptotic and pyroptotic signalling. Here the current knowledge on cell death pathways and how VACV proteins interact with them is reviewed. Studying the mechanisms evolved by VACV to counteract host programmed cell death has implications for its successful use as a vector for vaccination and as an oncolytic agent against cancer.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Veyer, David L
Carrara, Guia
Maluquer de Motes,
Smith, Geoffrey L
Date : 31 March 2017
Funders : BBSRC, Medical Research Council
DOI : 10.1016/j.imlet.2017.03.015
Copyright Disclaimer : © 2017 The Authors. Published by Elsevier B.V. on behalf of European Federation of Immunological Societies. This is an open access article under the CC BY-NC-ND license ( licenses/by-nc-nd/4.0/).
Uncontrolled Keywords : Apoptosis; Necroptosis; Pyroptosis; Vaccinia virus; Vaccines; Oncolytic viruses
Depositing User : Melanie Hughes
Date Deposited : 26 May 2017 11:43
Last Modified : 11 Dec 2018 11:23

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