Alginate electrodeposition onto three-dimensional porous Co-Ni films as drug delivery platforms.

García-Torres, J, Gispert, C, Gómez, E and Vallés, E (2015) Alginate electrodeposition onto three-dimensional porous Co-Ni films as drug delivery platforms. Phys Chem Chem Phys, 17 (3). pp. 1630-1636.

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Abstract

Three-dimensional porous Co-Ni films/alginate hybrid materials have been successfully prepared by electrodeposition to be used as a steerable magnetic device for drug delivery. Firstly, 3D porous Co-Ni films were prepared as substrates for the subsequent electrodeposition of the alginate biopolymer. Cyclic voltammetry, galvanostatic and potentiostatic studies were performed to establish the best conditions to obtain porous Co-Ni films. The electrochemical experiments were carried out in an electrolyte containing the metal salts and ammonium chloride at low pHs. In a second stage, the electrochemical deposition of alginate as a biocompatible polymer drug delivery carrier was performed. The characteristics of the alginate matrix were investigated in terms of electrochemical properties, morphology and drug release. The hybrid material obtained showed soft-magnetic behavior and drug release indicating its suitability to be used as a steerable magnetic drug delivery device.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	García-Torres, J, Gispert, C, Gómez, E and Vallés, E
Date :	21 January 2015
DOI :	10.1039/c4cp04389h
Uncontrolled Keywords :	Alginates, Cobalt, Drug Delivery Systems, Electroplating, Glucuronic Acid, Hemoglobins, Hexuronic Acids, Microscopy, Electron, Scanning, Nickel, Porosity, Surface Properties
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 13:31
Last Modified :	25 Jan 2020 00:03
URI:	http://epubs.surrey.ac.uk/id/eprint/839548

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