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Kinetics and equilibrium of solute diffusion into human hair.

Wang, L, Chen, L, Han, L and Lian, G (2012) Kinetics and equilibrium of solute diffusion into human hair. Ann Biomed Eng, 40 (12). pp. 2719-2726.

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The uptake kinetics of five molecules by hair has been measured and the effects of pH and physical chemical properties of molecules were investigated. A theoretical model is proposed to analyze the experimental data. The results indicate that the binding affinity of solute to hair, as characterized by hair-water partition coefficient, scales to the hydrophobicity of the solute and decreases dramatically as the pH increases to the dissociation constant. The effective diffusion coefficient of solute depended not only on the molecular size as most previous studies suggested, but also on the binding affinity as well as solute dissociation. It appears that the uptake of molecules by hair is due to both hydrophobic interaction and ionic charge interaction. Based on theoretical considerations of the cellular structure, composition and physical chemical properties of hair, quantitative-structure-property-relationships (QSPR) have been proposed to predict the hair-water partition coefficient (PC) and the effective diffusion coefficient (D (e)) of solute. The proposed QSPR models fit well with the experimental data. This paper could be taken as a reference for investigating the adsorption properties for polymeric materials, fibres, and biomaterials.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Wang, L
Chen, L
Han, L
Date : December 2012
DOI : 10.1007/s10439-012-0610-8
Uncontrolled Keywords : Biological Transport, Hair, Humans, Hydrogen-Ion Concentration, Kinetics, Models, Biological, Water
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 13:04
Last Modified : 24 Jan 2020 23:22

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