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Biological cell irradiation at ultrahigh dose rate employing laser driven protons

Doria, D, Kakolee, KF, Kar, S, Litt, SK, Fiorini, F, Ahmed, H, Green, S, Jeynes, JG, Kavanagh, J, Kirby, D , Kirkby, KJ, Lewis, CL, Merchant, MJ, Nersisyan, G, Prasad, R, Prise, KM, Schettino, G, Zepf, M and Borghesi, M (2012) Biological cell irradiation at ultrahigh dose rate employing laser driven protons AIP Conference Proceedings, 1462. pp. 135-138.

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The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. © 2012 American Institute of Physics.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Doria, D
Kakolee, KF
Kar, S
Litt, SK
Fiorini, F
Ahmed, H
Green, S
Jeynes, JG
Kavanagh, J
Kirby, D
Kirkby, KJ
Lewis, CL
Nersisyan, G
Prasad, R
Prise, KM
Schettino, G
Zepf, M
Borghesi, M
Date : 1 December 2012
DOI : 10.1063/1.4736777
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 12:42
Last Modified : 24 Jan 2020 22:41

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