Hyaluronic acid-based hydrogels crosslinked by copper-catalyzed azide-alkyne cycloaddition with tailorable mechanical properties.
Tools
Tools
Tools
Piluso, S, Hiebl, B, Gorb, SN, Kovalev, A, Lendlein, A and Neffe, AT (2011) Hyaluronic acid-based hydrogels crosslinked by copper-catalyzed azide-alkyne cycloaddition with tailorable mechanical properties. Int J Artif Organs, 34 (2). pp. 192-197.
Full text not available from this repository.Abstract
Biopolymers of the extracellular matrix are attractive starting materials for providing degradable and biocompatible biomaterials. In this study, hyaluronic acid-based hydrogels with tunable mechanical properties were prepared by the use of copper- catalyzed azide-alkyne cycloaddition (known as "click chemistry"). Alkyne-functionalized hyaluronic acid was crosslinked with linkers having two terminal azide functionalities, varying crosslinker density as well as the lengths and rigidity of the linker molecules. By variation of the crosslinker density and crosslinker type, hydrogels with elastic moduli in the range of 0.5-4 kPa were prepared. The washed materials contained a maximum of 6.8 mg copper per kg dry weight and the eluate of the gel crosslinked with diazidostilbene did not show toxic effects on L929 cells. The hyaluronic acid-based hydrogels have potential as biomaterials for cell culture or soft tissue regeneration applications.
| Item Type: | Article | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Divisions : | Surrey research (other units) | |||||||||||||||||||||
| Authors : |
|
|||||||||||||||||||||
| Date : | February 2011 | |||||||||||||||||||||
| DOI : | 10.5301/IJAO.2011.6394 | |||||||||||||||||||||
| Uncontrolled Keywords : | Adhesiveness, Alkynes, Animals, Azides, Biocompatible Materials, Cell Line, Cell Survival, Copper Sulfate, Cross-Linking Reagents, Diazonium Compounds, Elastic Modulus, Fibroblasts, Hyaluronic Acid, Hydrogels, Mice, Molecular Structure, Rheology, Stilbenes, Sulfonic Acids | |||||||||||||||||||||
| Depositing User : | Symplectic Elements | |||||||||||||||||||||
| Date Deposited : | 17 May 2017 12:23 | |||||||||||||||||||||
| Last Modified : | 24 Jan 2020 22:10 | |||||||||||||||||||||
| URI: | http://epubs.surrey.ac.uk/id/eprint/835157 |
Actions (login required)
 |
View Item |
Downloads
Downloads per month over past year