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Antimicrobial prenylated acetophenones from berries of Harrisonia abyssinica

Mayaka, RK, Langat, MK, Omolo, JO and Cheplogoi, PK (2012) Antimicrobial prenylated acetophenones from berries of Harrisonia abyssinica Planta Medica, 78 (4). pp. 383-386.

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The ripe berries of Harrisonia abyssinica yielded two new prenylated acetophenones, namely 5-(ethan-1‴-one)-4,6-dihydroxy-7-(3″, 3″-dimethylallyl)-2S-(1′S-hydroxy-1′,5′-dimethylhex- 4′-enyl)-2,3-dihydrobenzofuran (1) and 5-(2″′-hydroxyethan- 1″′-one)-4,6-dihydroxy-7-(3″,3″-dimethylallyl) -2S-(1′S-hydroxy-1′,5′-dimethylhex-4′-enyl)-2, 3-dihydrobenzofuran (2), herein named harronin I and harronin II, respectively. The compounds were isolated following activity guided fractionation and the structures were determined using 1D, 2D NMR spectroscopic, CD and MS spectrometric techniques. The methanol-dichloromethane mixture (1: 1 v/v) crude extract exhibited strong antimicrobial activity against Candida albicans, Bacillus cereus, Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, and Lactobacillus casei. Harronin I (1) showed a MIC of 5 μg/mL against C. albicans, 6 μg/mL against B. cereus, and more than 20 μg/mL against other tested microorganisms. Harronin II (2) showed much weaker MIC values (> 100 μg/mL) against all the tested microorganisms. © Georg Thieme Verlag KG Stuttgart.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Mayaka, RK
Omolo, JO
Cheplogoi, PK
Date : 11 January 2012
DOI : 10.1055/s-0031-1298143
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 12:23
Last Modified : 24 Jan 2020 22:09

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