Barrett's oesophagus is characterized by a predominantly humoral inflammatory response
Moons, LM, Kusters, JG, Bultman, E, Kuipers, EJ, van Dekken, H, Tra, WM, Kleinjan, A, Kwekkeboom, J, van Vliet, AH and Siersema, PD (2005) Barrett's oesophagus is characterized by a predominantly humoral inflammatory response Journal of Pathology, 207 (3). pp. 269-276.
Full text not available from this repository.Abstract
Barrett's oesophagus (BO) is thought to be an intermediate step in the progression from reflux oesophagitis (RO) to oesophageal adenocarcinoma. Premalignant conditions that develop in the presence of chronic inflammation are often associated with the development of a more pronounced humoral immune response during progression of the disease. The aim of this study was to determine whether BO is also associated with a more pronounced humoral immune response when compared to RO. Immunohistochemical studies were performed to quantify the mean numbers of Th2 effector cells (plasma cells and mast cells) and Th1 effector cells (macrophages and CD8+ T cells) to detect the antibody classes produced by plasma cells (IgA, IgG, IgM or IgE) and to determine the presence of isolated lymph follicles [segregated B and T cell areas, follicular dendritic cells (CD23) and expression of CXCL13] in 124 oesophageal biopsies from 20 patients with BO and 20 patients with RO. The proportion of Th2 effector cells was higher in BO than in RO, mainly due to higher numbers of plasma cells and mast cells in BO (p < 0.001). Most plasma cells in BO and RO expressed IgG, but several IgE+ plasma cells were detected in BO: these were rare in RO. In line with this, isolated lymph follicles were observed in 4/20 (20%) patients with BO, but not in RO. We therefore conclude that the inflammatory response is skewed towards a more pronounced humoral immune response when RO progresses to BO. It may be that this shift, which is similar to that found in other chronic inflammatory conditions, contributes to an increased cancer risk in BO.
Item Type: | Article | |||||||||||||||||||||||||||||||||
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Subjects : | Veterinary Medicine | |||||||||||||||||||||||||||||||||
Divisions : | Surrey research (other units) | |||||||||||||||||||||||||||||||||
Authors : |
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Date : | 21 September 2005 | |||||||||||||||||||||||||||||||||
DOI : | 10.1002/path.1847 | |||||||||||||||||||||||||||||||||
Copyright Disclaimer : | Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. | |||||||||||||||||||||||||||||||||
Depositing User : | Symplectic Elements | |||||||||||||||||||||||||||||||||
Date Deposited : | 17 May 2017 10:47 | |||||||||||||||||||||||||||||||||
Last Modified : | 24 Jan 2020 20:02 | |||||||||||||||||||||||||||||||||
URI: | http://epubs.surrey.ac.uk/id/eprint/829198 |
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