Mycobacterium ulcerans and Buruli Ulcer

Hall, BS, Simmonds, R, Benbow, ME, Mosi, L, Roberts, S and Williamso Jordan, H (2015) Mycobacterium ulcerans and Buruli Ulcer In: Human Emerging and Re-emerging Infections: Viral and Parasitic Infections, Volume I. John Wiley and Sons, Hoboken, NJ, USA.

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Abstract

Buruli Ulcer (BU) is the third most common mycobacterium disease following only tuberculosis and leprosy. Though BU is thought to be associated with large-and small-scale disturbances to the landscape and bodies of water frequented by human populations, primary prevention of BU is difficult because the mode of transmission is not known. This chapter reviews the most common environmental risk factors for BU and recent research into understanding its transmission. It is predicted that the proteins affected by mycolactone may share an underlying mechanism of production that could explain their co-regulation. Early work on the mechanism of suppression by mycolac-tone was carried out in Jurkat T cells using ASLs and focused on the suppression of IL-2 production. A multidisciplinary approach to treatment and patient care is essential for optimizing treatment outcomes. Physiotherapy is paramount minimizing and/or preventing disabilities.

Item Type:	Book Section
Divisions :	Surrey research (other units)
Authors :	Name Email ORCID Hall, BS b.s.hall@surrey.ac.uk Simmonds, R rachel.simmonds@surrey.ac.uk Benbow, ME Mosi, L Roberts, S Williamso Jordan, H
Editors :	Name Email ORCID Singh, SK
Date :	15 November 2015
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:45
Last Modified :	23 Jan 2020 16:12
URI:	http://epubs.surrey.ac.uk/id/eprint/829098

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