In Vitro Activity of Epigallocatechin Gallate and Quercetin Alone and in Combination versus Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

Betts, JW and Wareham, DW (2015) In Vitro Activity of Epigallocatechin Gallate and Quercetin Alone and in Combination versus Clinical Isolates of Methicillin-Resistant Staphylococcus aureus Journal of Natural Products, 78 (8). pp. 2145-2148.

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Abstract

Topical infections can become life threatening in immunocompromised patients. However, fewer treatments are available as multi-drug-resistant bacteria become more common. The natural compounds epigallocatechin gallate (1) and quercetin (2) alone and in combination were tested as potential antimicrobial clinical therapies. Strong antimicrobial activity was produced by 1 alone against methicillin-resistant Staphylococcus aureus, and activity was significantly increased in the presence of 2. A synergistic interaction was observed between the two compounds. Kill kinetics indicate the combination is bactericidal over 24 h.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Name Email ORCID Betts, JW jono.betts@surrey.ac.uk Wareham, DW
Date :	12 August 2015
DOI :	10.1021/acs.jnatprod.5b00471
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:43
Last Modified :	24 Jan 2020 19:56
URI:	http://epubs.surrey.ac.uk/id/eprint/828976

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