Providencia stuartii Isolates from Greece: Co-carriage of Cephalosporin (blaSHV-5, blaVEB-1), Carbapenem (blaVIM-1) and Aminoglycoside (RmtB) Resistance Determinants by a Multi-drug Resistant Outbreak Clone

Oikonomou, O, Liakopoulous, A, Phee, L, Betts, J, Mevius, D and Wareham, DW (2016) Providencia stuartii Isolates from Greece: Co-carriage of Cephalosporin (blaSHV-5, blaVEB-1), Carbapenem (blaVIM-1) and Aminoglycoside (RmtB) Resistance Determinants by a Multi-drug Resistant Outbreak Clone Microbial Drug Resistance: mechanism, epidemiology, and disease.

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Abstract

Providencia stuartii has emerged as an important nosocomial pathogen. We describe an outbreak due to a multidrug-resistant strain over a 4-month period in a critical care unit in Athens. Molecular typing revealed each of the isolates to be clonally related with coresistance to cephalosporins, carbapenems, aminoglycosides, and quinolones. Each isolate contained a 220-kb multi-replicon (IncA/C and IncR) conjugative plasmid encoding TEM-1, SHV-5, VEB-1, and VIM-1 β-lactamases and the 16S rDNA methylase RmtB. Antimicrobial therapy was unsuccessful in 3 of 6 cases, and resistance was readily transmissible to susceptible strains of Escherichia coli by transformation and conjugation. This highlights the clinical importance of P. stuartii and its ability to disseminate critical resistance determinants to other bacterial pathogens.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Name Email ORCID Oikonomou, O Liakopoulous, A Phee, L Betts, J jono.betts@surrey.ac.uk Mevius, D Wareham, DW
Date :	26 January 2016
DOI :	10.1089/mdr.2015.0215
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:43
Last Modified :	24 Jan 2020 19:55
URI:	http://epubs.surrey.ac.uk/id/eprint/828973

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