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Antigen translocation machineries in adaptive immunity and viral immune evasion

Mayerhofer, PU and Tampé, R (2015) Antigen translocation machineries in adaptive immunity and viral immune evasion J Mol Biol, 427. pp. 1102-1118.

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Protein homeostasis results in a steady supply of peptides, which are further degraded to fuel protein synthesis or metabolic needs of the cell. In higher vertebrates, a small fraction of the resulting peptidome, however, is translocated into the endoplasmic reticulum by the transporter associated with antigen processing (TAP). Antigenic peptides are guided to major histocompatibility complex class I (MHC I) molecules and are finally displayed on the cell surface, where they mount an adaptive immune response against viral infected or malignantly transformed cells. Here, we review the structural organization and the molecular mechanism of this specialized antigen translocon. We discuss how the ATP-binding cassette (ABC) transporter TAP communicates and cooperates within the multi-component peptide loading machinery, mediating the proper assembly and editing of kinetically stable peptide/MHC I complexes. In light of its important role within the MHC I antigen processing pathway, TAP is a prime target for viral immune evasion strategies, and we summarize how this antigen translocation machinery is sabotaged by viral factors. Finally, we compare TAP with other ABC systems that facilitate peptide translocation.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Tampé, R
Date : 2015
DOI : 10.1016/j.jmb.2014.09.006
Uncontrolled Keywords : ATP-Binding Cassette Transporters/immunology Adaptive Immunity/*immunology Animals Antigen Presentation/*immunology Antigens, Viral/*immunology Histocompatibility Antigens Class I/immunology Humans Immune Evasion/*immunology Protein Transport/immunology Viruses/*immunology
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:42
Last Modified : 24 Jan 2020 19:52

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