Renal & ocular targets for therapy in Wegener's granulomatosis.

Joshi, L, Hamour, S, Salama, AD, Pusey, CD, Lightman, S and Taylor, SR (2009) Renal & ocular targets for therapy in Wegener's granulomatosis. Inflamm Allergy Drug Targets, 8 (1). pp. 70-79.

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Abstract

Wegener's granulomatosis (WG) is a multisystem small-vessel vasculitis which is characterised by granulomatous inflammation. Respiratory tract involvement is most commonly seen, affecting up to 85% of patients, closely followed by the renal system in up to 75% of patients; ocular involvement in WG is estimated to occur in 50-60% of patients. The purpose of this review is to provide an overview of the renal and ocular manifestations of WG and discuss the rationale behind the therapeutic approach. In particular, we will focus on how understanding the disease processes in both of these organs has led to more targeted therapy. The mechanism of action of the various immunosuppressive medications in both systemic and ocular inflammation and the evidence available for their use will also be discussed.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Name Email ORCID Joshi, L Hamour, S Salama, AD Pusey, CD Lightman, S Taylor, SR s.r.taylor@surrey.ac.uk
Date :	March 2009
Uncontrolled Keywords :	Animals, Antibodies, Antineutrophil Cytoplasmic, Antibodies, Monoclonal, Antibodies, Monoclonal, Murine-Derived, Antigen-Antibody Reactions, Antigens, CD20, Autoimmunity, Cyclophosphamide, Glomerulonephritis, Granulomatosis with Polyangiitis, Humans, Immunosuppression, Prednisolone, Rituximab, Scleritis, Tumor Necrosis Factor-alpha, Vasculitis
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:41
Last Modified :	24 Jan 2020 19:51
URI:	http://epubs.surrey.ac.uk/id/eprint/828819

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