Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts.

Hampel, R, Peters, A, Beelen, R, Brunekreef, B, Cyrys, J, de Faire, U, de Hoogh, K, Fuks, K, Hoffmann, B, Hüls, A et al, Imboden, M, Jedynska, A, Kooter, I, Koenig, W, Künzli, N, Leander, K, Magnusson, P, Männistö, S, Penell, J, Pershagen, G, Phuleria, H, Probst-Hensch, N, Pundt, N, Schaffner, E, Schikowski, T, Sugiri, D, Tiittanen, P, Tsai, MY, Wang, M, Wolf, K, Lanki, T and ESCAPE TRANSPHORM study groups, (2015) Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts. Environ Int, 82. pp. 76-84.

Full text not available from this repository.

Abstract

BACKGROUND: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses. OBJECTIVES: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects. METHODS: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter <10μm (PM10) and <2.5μm (PM2.5) in diameter and selected elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) were estimated based on land-use regression models. Associations between components and inflammatory markers were estimated using linear regression models for each cohort separately. Cohort-specific results were combined using random effects meta-analysis. As a sensitivity analysis the models were additionally adjusted for PM mass. RESULTS: A 5ng/m(3) increase in PM2.5 copper and a 500ng/m(3) increase in PM10 iron were associated with a 6.3% [0.7; 12.3%] and 3.6% [0.3; 7.1%] increase in hsCRP, respectively. These associations between components and fibrinogen were slightly weaker. A 10ng/m(3) increase in PM2.5 zinc was associated with a 1.2% [0.1; 2.4%] increase in fibrinogen; confidence intervals widened when additionally adjusting for PM2.5. CONCLUSIONS: Long-term exposure to transition metals within ambient particulate matter, originating from traffic and industry, may be related to chronic systemic inflammation providing a link to long-term health effects of particulate matter.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Name Email ORCID Hampel, R Peters, A Beelen, R Brunekreef, B Cyrys, J de Faire, U de Hoogh, K Fuks, K Hoffmann, B Hüls, A Imboden, M Jedynska, A Kooter, I Koenig, W Künzli, N Leander, K Magnusson, P Männistö, S Penell, J j.penell@surrey.ac.uk Pershagen, G Phuleria, H Probst-Hensch, N Pundt, N Schaffner, E Schikowski, T Sugiri, D Tiittanen, P Tsai, MY Wang, M Wolf, K Lanki, T ESCAPE TRANSPHORM study groups,
Date :	September 2015
DOI :	10.1016/j.envint.2015.05.008
Uncontrolled Keywords :	ESCAPE, Elemental components, Inflammation, Long-term exposure, Particulate matter, TRANSPHORM, Biomarkers, C-Reactive Protein, Cohort Studies, Copper, Environmental Exposure, Europe, Female, Fibrinogen, Humans, Inflammation, Iron, Linear Models, Models, Theoretical, Nickel, Particulate Matter, Respiratory Tract Diseases, Sulfur, Time, Vanadium, Zinc
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:32
Last Modified :	24 Jan 2020 19:31
URI:	http://epubs.surrey.ac.uk/id/eprint/828169

Actions (login required)

View Item

Downloads