All translation elongation factors and the e, f, and h subunits of translation initiation factor 3 are encoded by 5'-terminal oligopyrimidine (TOP) mRNAs.
Tools
Tools
Tools
Iadevaia, V, Caldarola, S, Tino, E, Amaldi, F and Loreni, F (2008) All translation elongation factors and the e, f, and h subunits of translation initiation factor 3 are encoded by 5'-terminal oligopyrimidine (TOP) mRNAs. RNA, 14 (9). pp. 1730-1736.
Full text not available from this repository.Abstract
Terminal oligopyrimidine (TOP) mRNAs (encoded by the TOP genes) are identified by a sequence of 6-12 pyrimidines at the 5' end and by a growth-associated translational regulation. All vertebrate genes for the 80 ribosomal proteins and some other genes involved, directly or indirectly, in translation, are TOP genes. Among the numerous translation factors, only eEF1A and eEF2 are known to be encoded by TOP genes, most of the others having not been analyzed. Here, we report a systematic analysis of the human genes for translation factors. Our results show that: (1) all five elongation factors are encoded by TOP genes; and (2) among the initiation and termination factors analyzed, only eIF3e, eIF3f, and eIF3h exhibit the characteristics of TOP genes. Interestingly, these three polypeptides have been recently shown to constitute a specific subgroup among eIF3 subunits. In fact, eIF3e, eIF3f, and eIF3h are the part of the functional core of eIF3 that is not conserved in Saccharomyces cerevisiae. It has been hypothesized that they are regulatory subunits, and the fact that they are encoded by TOP genes may be relevant for their function.
| Item Type: | Article | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Divisions : | Surrey research (other units) | ||||||||||||||||||
| Authors : |
|
||||||||||||||||||
| Date : | September 2008 | ||||||||||||||||||
| DOI : | 10.1261/rna.1037108 | ||||||||||||||||||
| Uncontrolled Keywords : | Animals, Base Sequence, Conserved Sequence, Eukaryotic Initiation Factor-3, Genetic Code, HeLa Cells, Humans, Mice, NIH 3T3 Cells, Protein Subunits, RNA 5' Terminal Oligopyrimidine Sequence, RNA, Messenger, Saccharomyces cerevisiae | ||||||||||||||||||
| Related URLs : | |||||||||||||||||||
| Depositing User : | Symplectic Elements | ||||||||||||||||||
| Date Deposited : | 17 May 2017 10:28 | ||||||||||||||||||
| Last Modified : | 24 Jan 2020 19:24 | ||||||||||||||||||
| URI: | http://epubs.surrey.ac.uk/id/eprint/827941 |
Actions (login required)
 |
View Item |
Downloads
Downloads per month over past year