Ischemic preconditioning-an unfulfilled promise.

Williams, TM, Waksman, R, De Silva, K, Jacques, A and Mahmoudi, M (2015) Ischemic preconditioning-an unfulfilled promise. Cardiovasc Revasc Med, 16 (2). pp. 101-108.

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Abstract

Myocardial reperfusion injury has been identified as a key determinant of myocardial infarct size in patients undergoing percutaneous or surgical interventions. Although the molecular mechanisms underpinning reperfusion injury have been elucidated, attempts at translating this understanding into clinical benefit for patients undergoing cardiac interventions have produced mixed results. Ischemic conditioning has been applied before, during, or after an ischemic insult to the myocardium and has taken the form of local induction of ischemia or ischemia of distant tissues. Clinical studies have confirmed the safety of differing conditioning techniques, but the benefit of such techniques in reducing hard clinical event rates has produced mixed results. The aim of this article is to review the role of ischemic conditioning in patients undergoing percutaneous and surgical coronary revascularization.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Name Email ORCID Williams, TM Waksman, R De Silva, K Jacques, A Mahmoudi, M m.mahmoudi@surrey.ac.uk
Date :	March 2015
DOI :	10.1016/j.carrev.2014.12.010
Uncontrolled Keywords :	Cardiac surgery, Ischemic preconditioning, Percutaneous coronary intervention, Angioplasty, Balloon, Coronary, Coronary Angiography, Coronary Artery Bypass, Coronary Artery Disease, Female, Follow-Up Studies, Humans, Ischemic Preconditioning, Myocardial, Male, Myocardial Infarction, Myocardial Reperfusion Injury, Needs Assessment, Patient Safety, Severity of Illness Index, Treatment Outcome
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:28
Last Modified :	24 Jan 2020 19:23
URI:	http://epubs.surrey.ac.uk/id/eprint/827924

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