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Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators.

Cartledge, JE, Kane, C, Dias, P, Tesfom, M, Clarke, L, Mckee, B, Al Ayoubi, S, Chester, A, Yacoub, MH, Camelliti, P and Terracciano, CM (2015) Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators. Cardiovasc Res, 105 (3). pp. 260-270.

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Crosstalk between cardiomyocytes and fibroblasts in physiological conditions and during disease remains poorly defined. Previous studies have shown that fibroblasts and myocytes interact via paracrine communication, but several experimental confounding factors, including the use of immature myocytes and the induction of alpha-smooth muscle actin (α-SMA) expression in fibroblasts by prolonged culture, have hindered our understanding of this phenomenon. We hypothesize that fibroblasts and myofibroblasts differentially affect cardiomyocytes viability, volume, and Ca(2+) handling via soluble mediators. More specifically here: (i) we compare the effects of freshly isolated fibroblasts and cultured fibroblasts from normal rat hearts on adult cardiomyocytes; (ii) we compare the effects of (freshly isolated) normal fibroblasts and myofibroblasts from pressure-overloaded hearts; and (iii) we study the contribution of TGF-β and the importance of the crosstalk between the two cell types.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Cartledge, JE
Kane, C
Dias, P
Tesfom, M
Clarke, L
Mckee, B
Al Ayoubi, S
Chester, A
Yacoub, MH
Terracciano, CM
Date : 1 March 2015
DOI : 10.1093/cvr/cvu264
Uncontrolled Keywords : Calcium handling, Fibroblasts, Paracrine communication, TGF-β
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:28
Last Modified : 24 Jan 2020 19:22

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