Exercise and 24-h glycemic control: equal effects for all type 2 diabetes patients?

Van Dijk, JW, Manders, RJ, Canfora, EE, Mechelen, WV, Hartgens, F, Stehouwer, CD and Van Loon, LJ (2013) Exercise and 24-h glycemic control: equal effects for all type 2 diabetes patients? Med Sci Sports Exerc, 45 (4). pp. 628-635.

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Abstract

PURPOSE: We assessed the effect of a single bout of moderate-intensity exercise on subsequent 24-h glycemic control in 60 type 2 diabetes patients. Moreover, we examined whether individual responses to exercise were related to subjects' baseline characteristics, including age, body mass index, diabetes duration, exercise performance, medication, and HbA1c content. METHODS: Sixty type 2 diabetes patients (insulin-treated, n = 23) participated in a randomized crossover experiment. Patients were studied on two occasions for 3 d under strict dietary standardization but otherwise free-living conditions. Parameters of glycemic control (means [95% confidence interval]) were assessed by continuous glucose monitoring over the 24-h period after a single bout of moderate-intensity endurance-type exercise or no exercise at all (control). RESULTS: Type 2 diabetes patients experienced hyperglycemia (blood glucose >10 mmol·L) for as much as 8:16 h:min (6:44 to 9:48 h:min) per day. The prevalence of hyperglycemia was reduced by 31% to 5:38 h:min (3:17 to 7:00 h:min) over the 24-h period after the exercise bout (P < 0.001). Moreover, exercise lowered average blood glucose concentrations by 0.9 mmol·L (0.7 to 1.2) and reduced glycemic variability (P < 0.05). The response to exercise showed considerable variation between subjects and correlated positively with HbA1c levels (r = 0.38, P < 0.01). Nevertheless, even well-controlled patients with an HbA1c level below 7.0% (n = 28) achieved a 28% reduction in the daily prevalence hyperglycemia after exercise (P < 0.01). CONCLUSIONS: A single bout of moderate-intensity exercise substantially improves glycemic control throughout the subsequent day in insulin- and non-insulin-treated type 2 diabetes patients. Of all baseline characteristics, only subjects' HbA1c level is related to the magnitude of response to exercise. Nevertheless, the present study demonstrates that even well-controlled patients benefit considerably from the blood glucose-lowering properties of daily exercise.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Name Email ORCID Van Dijk, JW Manders, RJ r.manders@surrey.ac.uk Canfora, EE Mechelen, WV Hartgens, F Stehouwer, CD Van Loon, LJ
Date :	April 2013
DOI :	10.1249/MSS.0b013e31827ad8b4
Uncontrolled Keywords :	Aged, Blood Glucose, Cross-Over Studies, Diabetes Mellitus, Type 2, Exercise, Humans, Hyperglycemia, Middle Aged, Netherlands, Time Factors
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:22
Last Modified :	24 Jan 2020 19:06
URI:	http://epubs.surrey.ac.uk/id/eprint/827492

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