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Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE).

Fuks, KB, Weinmayr, G, Foraster, M, Dratva, J, Hampel, R, Houthuijs, D, Oftedal, B, Oudin, A, Panasevich, S, Penell, J , Sommar, JN, Sørensen, M, Tiittanen, P, Wolf, K, Xun, WW, Aguilera, I, Basagaña, X, Beelen, R, Bots, ML, Brunekreef, B, Bueno-de-Mesquita, HB, Caracciolo, B, Cirach, M, de Faire, U, de Nazelle, A, Eeftens, M, Elosua, R, Erbel, R, Forsberg, B, Fratiglioni, L, Gaspoz, JM, Hilding, A, Jula, A, Korek, M, Krämer, U, Künzli, N, Lanki, T, Leander, K, Magnusson, PK, Marrugat, J, Nieuwenhuijsen, MJ, Ostenson, CG, Pedersen, NL, Pershagen, G, Phuleria, HC, Probst-Hensch, NM, Raaschou-Nielsen, O, Schaffner, E, Schikowski, T, Schindler, C, Schwarze, PE, Søgaard, AJ, Sugiri, D, Swart, WJ, Tsai, MY, Turunen, AW, Vineis, P, Peters, A and Hoffmann, B (2014) Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Environ Health Perspect, 122 (9). pp. 896-905.

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BACKGROUND: Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific. OBJECTIVES: We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hypertension in European populations. METHODS: We analyzed 15 population-based cohorts, participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE). We modeled residential exposure to particulate matter and nitrogen oxides with land use regression using a uniform protocol. We assessed traffic exposure with traffic indicator variables. We analyzed systolic and diastolic BP in participants medicated and nonmedicated with BP-lowering medication (BPLM) separately, adjusting for personal and area-level risk factors and environmental noise. Prevalent hypertension was defined as ≥ 140 mmHg systolic BP, or ≥ 90 mmHg diastolic BP, or intake of BPLM. We combined cohort-specific results using random-effects meta-analysis. RESULTS: In the main meta-analysis of 113,926 participants, traffic load on major roads within 100 m of the residence was associated with increased systolic and diastolic BP in nonmedicated participants [0.35 mmHg (95% CI: 0.02, 0.68) and 0.22 mmHg (95% CI: 0.04, 0.40) per 4,000,000 vehicles × m/day, respectively]. The estimated odds ratio (OR) for prevalent hypertension was 1.05 (95% CI: 0.99, 1.11) per 4,000,000 vehicles × m/day. Modeled air pollutants and BP were not clearly associated. CONCLUSIONS: In this first comprehensive meta-analysis of European population-based cohorts, we observed a weak positive association of high residential traffic exposure with BP in nonmedicated participants, and an elevated OR for prevalent hypertension. The relationship of modeled air pollutants with BP was inconsistent.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Fuks, KB
Weinmayr, G
Foraster, M
Dratva, J
Hampel, R
Houthuijs, D
Oftedal, B
Oudin, A
Panasevich, S
Sommar, JN
Sørensen, M
Tiittanen, P
Wolf, K
Xun, WW
Aguilera, I
Basagaña, X
Beelen, R
Bots, ML
Brunekreef, B
Bueno-de-Mesquita, HB
Caracciolo, B
Cirach, M
de Faire, U
de Nazelle, A
Eeftens, M
Elosua, R
Erbel, R
Forsberg, B
Fratiglioni, L
Gaspoz, JM
Hilding, A
Jula, A
Korek, M
Krämer, U
Künzli, N
Lanki, T
Leander, K
Magnusson, PK
Marrugat, J
Nieuwenhuijsen, MJ
Ostenson, CG
Pedersen, NL
Pershagen, G
Phuleria, HC
Probst-Hensch, NM
Raaschou-Nielsen, O
Schaffner, E
Schikowski, T
Schindler, C
Schwarze, PE
Søgaard, AJ
Sugiri, D
Swart, WJ
Tsai, MY
Turunen, AW
Vineis, P
Peters, A
Hoffmann, B
Date : September 2014
DOI : 10.1289/ehp.1307725
Uncontrolled Keywords : Air Pollutants, Air Pollution, Antihypertensive Agents, Arterial Pressure, Cross-Sectional Studies, Environmental Exposure, Europe, Female, Humans, Hypertension, Male, Nitrogen Oxides, Noise, Transportation, Particulate Matter, Risk Factors, Vehicle Emissions
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:18
Last Modified : 24 Jan 2020 18:58

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