University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Stereological and allometric studies on neurons and axo-dendritic synapses in the superior cervical ganglia of rats, capybaras and horses.

Loesch, A, Mayhew, TM, Tang, H, Ladd, FV, Ladd, AA, de Melo, MP, da Silva, AA and Coppi, AA (2010) Stereological and allometric studies on neurons and axo-dendritic synapses in the superior cervical ganglia of rats, capybaras and horses. Cell Tissue Res, 341 (2). pp. 223-237.

Full text not available from this repository.


The superior cervical ganglion (SCG) in mammals varies in structure according to developmental age, body size, gender, lateral asymmetry, the size and nuclear content of neurons and the complexity and synaptic coverage of their dendritic trees. In small and medium-sized mammals, neuron number and size increase from birth to adulthood and, in phylogenetic studies, vary with body size. However, recent studies on larger animals suggest that body weight does not, in general, accurately predict neuron number. We have applied design-based stereological tools at the light-microscopic level to assess the volumetric composition of ganglia and to estimate the numbers and sizes of neurons in SCGs from rats, capybaras and horses. Using transmission electron microscopy, we have obtained design-based estimates of the surface coverage of dendrites by postsynaptic apposition zones and model-based estimates of the numbers and sizes of synaptophysin-labelled axo-dendritic synaptic disks. Linear regression analysis of log-transformed data has been undertaken in order to establish the nature of the relationships between numbers and SCG volume (V(scg)). For SCGs (five per species), the allometric relationship for neuron number (N) is N=35,067xV (scg) (0.781) and that for synapses is N=20,095,000xV (scg) (1.328) , the former being a good predictor and the latter a poor predictor of synapse number. Our findings thus reveal the nature of SCG growth in terms of its main ingredients (neurons, neuropil, blood vessels) and show that larger mammals have SCG neurons exhibiting more complex arborizations and greater numbers of axo-dendritic synapses.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Loesch, A
Mayhew, TM
Tang, H
Ladd, FV
Ladd, AA
de Melo, MP
da Silva, AA
Date : August 2010
DOI : 10.1007/s00441-010-1002-8
Uncontrolled Keywords : Animals, Axons, Cell Enlargement, Cell Proliferation, Dendrites, Horses, Male, Neurons, Rats, Rats, Wistar, Rodentia, Sex Characteristics, Superior Cervical Ganglion, Synapses, Synaptophysin
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:11
Last Modified : 24 Jan 2020 18:40

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800