Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity

Smith, GL, Benfield, CT, Maluquer de Motes, C, Mazzon, M, Ember, SW, Ferguson, BJ and Sumner, RP (2013) Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity J Gen Virol, 94 (Pt 11). pp. 2367-2392.

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Abstract

Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity. In response, viruses have evolved many countermeasures that enable them to replicate and be transmitted to new hosts, despite the host innate immune response. Poxviruses, such as vaccinia virus (VACV), have large DNA genomes and encode many proteins that are dedicated to host immune evasion. Some of these proteins are secreted from the infected cell, where they bind and neutralize complement factors, interferons, cytokines and chemokines. Other VACV proteins function inside cells to inhibit apoptosis or signalling pathways that lead to the production of interferons and pro-inflammatory cytokines and chemokines. In this review, these VACV immunomodulatory proteins are described and the potential to create more immunogenic VACV strains by manipulation of the gene encoding these proteins is discussed.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Name Email ORCID Smith, GL Benfield, CT Maluquer de Motes, C c.maluquerdemotes@surrey.ac.uk Mazzon, M Ember, SW Ferguson, BJ Sumner, RP
Date :	November 2013
DOI :	10.1099/vir.0.055921-0
Uncontrolled Keywords :	Animals, Humans, Immune Evasion, Immunomodulation, Vaccinia, Vaccinia virus, Viral Proteins, Virulence
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:01
Last Modified :	24 Jan 2020 18:17
URI:	http://epubs.surrey.ac.uk/id/eprint/826038

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