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Inherited myopathy of great Danes.

Lujan Feliu-Pascual, A, Shelton, GD, Targett, MP, Long, SN, Comerford, EJ, McMillan, C, Davies, D, Rusbridge, C, Mellor, D, Chang, KC and Anderson, TJ (2006) Inherited myopathy of great Danes. J Small Anim Pract, 47 (5). pp. 249-254.

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A hereditary, non-inflammatory myopathy occurring in young great Danes with distinctive histological features in muscle biopsy specimens is reviewed. Onset of clinical signs is usually before one year of age and both sexes are affected. Clinical signs are characterised by exercise intolerance, muscle wasting, and an exercise-induced tremor. Although most affected dogs have a severe form of the disease, occasional dogs may have a less pronounced form and survive into adulthood with an acceptable quality of life. Litters containing affected puppies are born to clinically unaffected parents, and an autosomal recessive pattern of inheritance is likely. All recorded cases have had fawn or brindle coat coloration. Elevated serum creatinine kinase concentrations and spontaneous electrical activity in skeletal muscles are frequently found. While originally reported (Targett and others 1994) as a central core myopathy in this breed, the histochemical characteristics of the distinct cytoarchitectural structures differ from those of the well-characterised central core myopathy in human beings. In fact, these structures differ from any known myopathy in human beings and likely represents a unique non-inflammatory myopathy affecting dogs. Until this myopathy is characterised further, the name inherited myopathy in great Danes is suggested.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Lujan Feliu-Pascual, A
Shelton, GD
Targett, MP
Long, SN
Comerford, EJ
McMillan, C
Davies, D
Mellor, D
Chang, KC
Anderson, TJ
Date : May 2006
DOI : 10.1111/j.1748-5827.2006.00073.x
Uncontrolled Keywords : Animals, Animals, Newborn, Dog Diseases, Dogs, Female, Genes, Recessive, Genetic Predisposition to Disease, Male, Muscle, Skeletal, Muscular Diseases
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:54
Last Modified : 24 Jan 2020 17:58

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