University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection.

Hingley-Wilson, SM, Casey, R, Connell, D, Bremang, S, Evans, JT, Hawkey, PM, Smith, GE, Jepson, A, Philip, S, Kon, OM and Lalvani, A (2013) Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection. Emerg Infect Dis, 19 (7). pp. 1138-1141.

Full text not available from this repository.


Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Hingley-Wilson, SM
Connell, D
Bremang, S
Evans, JT
Hawkey, PM
Smith, GE
Jepson, A
Philip, S
Kon, OM
Lalvani, A
Date : July 2013
DOI : 10.3201/1907.130313
Uncontrolled Keywords : Mycobacterium tuberculosis, TB, antimicrobial resistance, bacteria, co-infection, drug sensitive, multidrug resistant, treatment resistance, tuberculosis and other mycobacteria, Aged, Antitubercular Agents, Coinfection, Culture Techniques, Delayed Diagnosis, Drug Resistance, Multiple, Bacterial, Drug Therapy, Combination, Ethambutol, Humans, Isoniazid, Male, Minisatellite Repeats, Molecular Diagnostic Techniques, Multilocus Sequence Typing, Mycobacterium tuberculosis, Treatment Outcome, Tuberculosis, Multidrug-Resistant, Tuberculosis, Pulmonary
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:53
Last Modified : 24 Jan 2020 17:56

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800