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UCHL-1 is not a Parkinson's disease susceptibility gene.

Healy, DG, Abou-Sleiman, PM, Casas, JP, Ahmadi, KR, Lynch, T, Gandhi, S, Muqit, MM, Foltynie, T, Barker, R, Bhatia, KP , Quinn, NP, Lees, AJ, Gibson, JM, Holton, JL, Revesz, T, Goldstein, DB and Wood, NW (2006) UCHL-1 is not a Parkinson's disease susceptibility gene. Ann Neurol, 59 (4). pp. 627-633.

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OBJECTIVE: The UCHL-1 gene is widely cited as a susceptibility factor for sporadic Parkinson's disease (PD). The strongest evidence comes from a meta-analysis of small studies that reported the S18Y polymorphism as protective against PD, after pooling studies of white and Asian subjects. Here, we present data that challenge this association. METHODS: In a new large case-control study in white individuals (3,023 subjects), the S18Y variant was not protective against PD under any genetic model of inheritance. Similarly, a more powerful haplotype-tagging approach did not detect other associated variants. RESULTS: Finally, in an updated S18Y-PD meta-analysis (6,594 subjects), no significant association was observed under additive, recessive, or dominant models (odds ratio = 1.00 [95% confidence interval: 0.74-1.33]; odds ratio = 1.01 [95% confidence interval: 0.76-1.35]; and odds ratio = 0.96 [95% confidence interval: 0.86-1.08], respectively), and a cumulative meta-analysis showed a trend toward a null effect. INTERPRETATION: Based on the current evidence, the UCHL-1 gene does not exhibit a protective effect in PD.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Healy, DG
Abou-Sleiman, PM
Casas, JP
Lynch, T
Gandhi, S
Muqit, MM
Foltynie, T
Barker, R
Bhatia, KP
Quinn, NP
Lees, AJ
Gibson, JM
Holton, JL
Revesz, T
Goldstein, DB
Wood, NW
Date : April 2006
DOI : 10.1002/ana.20757
Uncontrolled Keywords : Case-Control Studies, Confidence Intervals, Female, Genotype, Humans, Linkage Disequilibrium, Male, Meta-Analysis as Topic, Middle Aged, Odds Ratio, Parkinson Disease, Polymorphism, Genetic, Serine, Tyrosine, Ubiquitin Thiolesterase
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:48
Last Modified : 24 Jan 2020 17:42

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