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Nutrient-gene interactions in benefit-risk analysis.

Hesketh, J, Wybranska, I, Dommels, Y, King, M, Elliott, R, Pico, C and Keijer, J (2006) Nutrient-gene interactions in benefit-risk analysis. Br J Nutr, 95 (6). pp. 1232-1236.

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Individuals respond differently to nutrients and foods. This is reflected in different levels of benefits and risks at the same intake of a nutrient and, consequently, different 'windows of benefit' in terms of nutrient intake. This has led recently to the concept of 'personalised nutrition'. Genetic factors such as single nucleotide polymorphisms may be one source of this inter-individual variation in benefit-risk response to nutrients. In 2004 a European Union-funded network of excellence in the area of nutrigenomics (European Nutrigenomics Organisation; NuGO) organised a workshop on the role of nutrient-gene interactions in determining benefit-risk of nutrients and diet. The major issues discussed at the workshop are presented in the present paper and highlighted with examples from the presentations. The overall consensus was that although genetics provides a new vision where genetic information could in the future be used to provide knowledge on disease predisposition and nutritional requirements, such a goal is still far off and much more research is required before we can reliably include genetic factors in the risk-benefit assessment of nutrients and diets.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Hesketh, J
Wybranska, I
Dommels, Y
King, M
Pico, C
Keijer, J
Date : June 2006
Uncontrolled Keywords : Diet, Genetic Predisposition to Disease, Genetic Variation, Genome, Human, Humans, Nutritional Physiological Phenomena, Polymorphism, Single Nucleotide, Risk Assessment
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:35
Last Modified : 24 Jan 2020 17:13

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