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HIV-1 subtypes and the HIV epidemics in four cities in sub-Saharan Africa

Morison, L, Buve, A, Zekeng, L, Heyndrickx, L, Anagonou, S, Musonda, R, Kahindo, M, Weiss, HA, Hayes, RJ, Laga, M , Janssens, W and van der Groen, G (2001) HIV-1 subtypes and the HIV epidemics in four cities in sub-Saharan Africa AIDS, 15. S109-S116.

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Objective: To describe the distribution of HIV-1 subtypes in two cities with high HIV prevalence (Kisumu, Kenya and Ndola, Zambia) and two with relatively low prevalence (Cotonou, Benin and Yaoundé, Cameroon), and to examine whether the differences in prevalence of HIV infection could be due to the predominance within the infected populations of subtypes with differing efficiency of heterosexual transmission.

Methods: For around 100 randomly selected HIV-positive sera from the general population and 60 from sex workers in each city, the HIV-1 subtype was determined in the env fragment. For between 19 and 52 of the sera from the general population and 20-32 sera from sex workers, the subtype was also determined in the gag fragment.

Results: Over 70% of infections in Cotonou, Yaoundé and Kisumu were with subtype A (by env). However, around one-half of subtype A infections in Cotonou and Yaoundé were found to be the circulating recombinant form CRF02_AG when the gag fragment was also examined. A large number of different HIV strains were found in Yaoundé, including some belonging to group O. Over 20% of infections in Kisumu and around 10% in Yaoundé were with isolated intersubtype recombinant forms. All but a few infections in Ndola were with subtype C and no recombinants were found.

Conclusions: The pattern of distribution of subtypes that we found does not suggest that differences in circulating subtypes play a major role in explaining the differences in prevalence of HIV-1 infection between the four cities. The emergence and spread of recombinants requires close surveillance to adapt testing strategies if needed, to inform vaccine development and to ascertain their role in the future spread of HIV.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
Buve, A
Zekeng, L
Heyndrickx, L
Anagonou, S
Musonda, R
Kahindo, M
Weiss, HA
Hayes, RJ
Laga, M
Janssens, W
van der Groen, G
Date : 1 August 2001
DOI : 10.1097/00002030-200108004-00012
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, Virology, IMMUNOLOGY, INFECTIOUS DISEASES, VIROLOGY, Africa, HIV-1 subtypes, heterosexual transmission, HUMAN-IMMUNODEFICIENCY-VIRUS, POLYMERASE-CHAIN-REACTION, TYPE-1, TRANSMISSION, PREDOMINANCE, VARIABILITY, GENOTYPES, CAMEROON, NIGERIA
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:25
Last Modified : 25 Oct 2018 15:06

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