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The safety and tolerability of GLP-1 receptor agonists in the treatment of type-2 diabetes.

Russell-Jones, D (2010) The safety and tolerability of GLP-1 receptor agonists in the treatment of type-2 diabetes. Int J Clin Pract, 64 (10). pp. 1402-1414.

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Established therapies for type-2 diabetes effectively reduce blood glucose, but are often associated with adverse effects that pose risks to patient's health or diminish adherence to treatment. Weight gain, hypoglycaemia and gastrointestinal symptoms are commonly reported and some agents may not be safe for use in patients with renal impairment or elevated cardiovascular risk. New treatments based on the action of the endogenous human hormone glucagon-like peptide-1 (GLP-1), including exenatide and liraglutide, are available. These therapies provide a novel pharmacological approach to glycaemic control via multiple mechanisms of action, and accordingly exhibit different safety and tolerability profiles than conventional treatments. GLP-1 receptor agonists stimulate insulin release only in the presence of elevated blood glucose and are therefore associated with a fairly low risk of hypoglycaemia. Gastrointestinal symptoms are common but transient, and there appears to be little potential for interaction with other drugs. GLP-1 receptor agonists are associated with weight loss rather than weight gain. As protein-based therapies, these agents have the potential to induce antibody formation, but the impact on efficacy and safety is minor. GLP-1 receptor agonists thus offer a new and potentially useful option for clinicians concerned about some of the common adverse effects of type-2 diabetes therapies.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Date : September 2010
DOI : 10.1111/j.1742-1241.2010.02465.x
Uncontrolled Keywords : Diabetes Mellitus, Type 2, Drug Interactions, Drug-Induced Liver Injury, Gastrointestinal Diseases, Glucagon-Like Peptide 1, Heart Diseases, Humans, Hypoglycemia, Hypoglycemic Agents, Incretins, Insulin, Kidney Diseases, Pancreatitis, Receptors, Glucagon, Sulfonylurea Compounds, Thiazolidinediones, Thyroid Diseases
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:15
Last Modified : 24 Jan 2020 16:26

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