University of Surrey

Test tubes in the lab Research in the ATI Dance Research

The significance of sleep physiological disturbances in depression.

van den Hoofdakker, RH, Beersma, DG and Dijk, DJ (1987) The significance of sleep physiological disturbances in depression. Acta Psychiatr Belg, 87 (3). pp. 302-316.

Full text not available from this repository.


Since the discovery of the antidepressant effects of interventions in the sleep-wake cycle, a number of hypotheses have emerged according to which disturbances in sleep physiology are not merely expressions but essential components of the pathophysiology of depression. Three hypotheses are presented, the "Phase-advance", the "S-deficiency" and the "ACh-hypersensitivity" hypotheses. They explain the therapeutic effects of total, partial and selective sleep deprivation as consequences of the normalization of disturbed sleep regulation. The question is dealt with whether there are indications that the hypothesized sleep regulatory disturbances exist and whether there is a relationship between the effects of sleep deprivation on sleep regulation and clinical state. None of the hypotheses is totally supported, none can be fully rejected.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
van den Hoofdakker, RH
Beersma, DG
Date : May 1987
Uncontrolled Keywords : Circadian Rhythm, Depressive Disorder, Electroencephalography, Homeostasis, Humans, Male, Middle Aged, Models, Biological, Sleep, Sleep Deprivation, Sleep, REM
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:11
Last Modified : 24 Jan 2020 16:14

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800