Pegvisomant improves insulin sensitivity and reduces overnight free fatty acid concentrations in patients with acromegaly.

Higham, CE, Rowles, S, Russell-Jones, D, Umpleby, AM and Trainer, PJ (2009) Pegvisomant improves insulin sensitivity and reduces overnight free fatty acid concentrations in patients with acromegaly. J Clin Endocrinol Metab, 94 (7). pp. 2459-2463.

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Abstract

Acromegaly is complicated by an increased incidence of diabetes mellitus caused by impaired insulin sensitivity and reduced beta-cell function. Pegvisomant blocks activity at GH receptors, normalizing IGF-I in over 90% of patients and improving insulin sensitivity. The mechanisms for this increase in insulin sensitivity are not fully determined. We used stable isotope techniques to investigate the effects of pegvisomant on glucose and lipid metabolism in acromegaly.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Name Email ORCID Higham, CE Rowles, S Russell-Jones, D davidrussell-jones@nhs.net Umpleby, AM Trainer, PJ
Date :	July 2009
DOI :	10.1210/jc.2008-2086
Uncontrolled Keywords :	Acromegaly, Adult, Circadian Rhythm, Fatty Acids, Nonesterified, Female, Glucose, Hormone Antagonists, Human Growth Hormone, Humans, Insulin Resistance, Insulin-Like Growth Factor I, Lipid Metabolism, Longitudinal Studies, Male, Middle Aged, Osmolar Concentration
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 09:04
Last Modified :	24 Jan 2020 15:58
URI:	http://epubs.surrey.ac.uk/id/eprint/822172

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