Childhood predictors of cardiovascular disease in adulthood. A systematic review and meta-analysis

Ajala, O, Mold, Freda Elizabeth, Boughton, C, Cooke, Deborah and Whyte, Martin (2017) Childhood predictors of cardiovascular disease in adulthood. A systematic review and meta-analysis Obesity Reviews, 18 (9). pp. 1061-1070.

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Abstract

Childhood obesity predicts the risk of adult adiposity, which is associated with the earlier onset of cardiovascular disease [adult atherosclerotic cardiovascular disease, ACVD: hypertension, increased carotid intima media thickness (CIMT) stroke, ischemic heart disease (IHD)] and dysglycemia. Because it is not known whether childhood obesity contributes to these diseases, we conducted a systematic review of studies that examine the ability of measures of obesity in childhood to predict dysglycemia and ACVD. Data sources were: Web of Science, MEDLINE, PubMed, CINAHL, Cochrane, SCOPUS, ProQuest, and reference lists. Studies measuring BMI, SF, and WC were selected; of 1954 studies, 18 met study criteria. Results: Childhood BMI predicted CIMT: OR, 3.39 (95% CI, 2.02 to 5.67, P <0.001) and risk of impaired glucose tolerance in adulthood, but its ability to predict ACVD events (stroke, IHD; OR, 1.04; 95% CI, 1.02 to 1.07; P<0.001) and hypertension (OR, 1.17, 95% CI 1.06 to 1.27, P = 0.003), was weak-moderate. BMI was not predictive of systolic BP (r -0.57, P =0.08) and weakly predicted diastolic BP (r 0.21, P =0.002). SF in childhood weakly predicted CIMT in female adults only (r58 s0.09, P <0.05). Conclusion: Childhood BMI predicts the risk of dysglycemia and abnormal CIMT in adulthood but its ability to predict hypertension and ACVD events was weak and moderate respectively. SF was a weak predictor of CIMT in female adults.

Item Type:	Article
Subjects :	Biosciences and Medicine
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :	Name Email ORCID Ajala, O Mold, Freda Elizabeth Freda.mold@surrey.ac.uk Boughton, C Cooke, Deborah d.cooke@surrey.ac.uk Whyte, Martin m.b.whyte@surrey.ac.uk
Date :	25 May 2017
DOI :	10.1111/obr.12561
Copyright Disclaimer :	This is the peer reviewed version of the following article: Ajala, O., Mold, F., Boughton, C., Cooke, D., and Whyte, M. (2017) Childhood predictors of cardiovascular disease in adulthood. A systematic review and meta-analysis. Obesity Reviews, doi: 10.1111/obr.12561, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/obr.12561/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords :	Childhood, Obesity, Cardiovascular disease, risk factors
Related URLs :	Publisher
Depositing User :	Symplectic Elements
Date Deposited :	25 Apr 2017 17:58
Last Modified :	16 Jan 2019 17:14
URI:	http://epubs.surrey.ac.uk/id/eprint/814022

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