Supercritical fluid coating of API on excipient enhances drug release

Liu, Q, Huang, D, Lu, T, Seville, Jonathan, Xing, L and Leeke, GA (2016) Supercritical fluid coating of API on excipient enhances drug release Chemical Engineering Journal, 313. pp. 317-327.

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Abstract

A process to coat particles of active pharmaceutical ingredient (API) onto microcrystalline cellulose (MCC) excipient shows promise as a new way to dosage forms showing enhanced drug release. The process consists of a fluidized bed operated at elevated pressure in which API particles are precipitated from a Supercritical Anti-Solvent process (SAS). MCC particles were used as an excipient in the fluidized bed and collect the SAS-generated API particles. Naringin was selected as the model API to coat onto MCC. A number of operational parameters of the process were investigated: fluidization velocity, coating pressure, temperature, concentration of drug solution, drug solution flow rate, drug mass, organic solvent, MCC mass and size and CO2-to-organic solution ratio. SEM and SPM analyses showed that the MCC particle surfaces were covered with near-spherical nanoparticles with a diameter of approximately 100– 200 nm, substantially smaller than the as-received API material. XRD showed that naringin changed from crystalline to amorphous during processing. The coated particles resulting from the SAS fluidized bed process have a higher loading of API, gave faster release rates and higher release ratios in comparison with those produced using a conventional fluidized bed coating process. The approach could be transferred to other industries where release is important such as agrochemical, cosmetic and food.

Item Type:	Article
Subjects :	Chemical & Process Engineering
Divisions :	Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :	Name Email ORCID Liu, Q Huang, D Lu, T Seville, Jonathan J.P.K.Seville@surrey.ac.uk Xing, L Leeke, GA
Date :	18 December 2016
DOI :	10.1016/j.cej.2016.12.066
Copyright Disclaimer :	Copyright 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords :	Supercritical Anti-Solvent Fluidized bed coating Naringin Release profile Nanoparticles
Depositing User :	Symplectic Elements
Date Deposited :	25 Apr 2017 14:24
Last Modified :	16 Jan 2019 17:14
URI:	http://epubs.surrey.ac.uk/id/eprint/814017

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