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New advances in CMV and immunosenescence

Sansoni, P, Vescovini, R, Fagnoni, FF, Akbar, A, Arens, R, Chiu, Y-L, Čičin-Šain, L, Dechanet-Merville, J, Derhovanessian, E, Ferrando-Martinez, S , Franceschi, C, Frasca, D, Fulöp, T, Furman, D, Gkrania-Klotsas, E, Goodrum, F, Grubeck-Loebenstein, B, Hurme, M, Kern, F, Lilleri, D, López-Botet, M, Maier, AB, Marandu, T, Marchant, A, Matheï, C, Moss, P, Muntasell, A, Remmerswaal, EBM, Riddell, N, Rothe, K, Sauce, D, Shin, E-C, Simanek, AM, Smithey, MJ, Söderberg-Nauclér, C, Solana, R, Thomas, PG, van Lier, R, Pawelec, G and Nikolich-Zugich, J (2014) New advances in CMV and immunosenescence Experimental Gerontology, 55. pp. 54-62.

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Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on “CMV & Immunosenescence”, held in Parma, Italy, 25–27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.

Item Type: Article
Subjects : Biosciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Sansoni, P
Vescovini, R
Fagnoni, FF
Akbar, A
Arens, R
Chiu, Y-L
Čičin-Šain, L
Dechanet-Merville, J
Derhovanessian, E
Ferrando-Martinez, S
Franceschi, C
Frasca, D
Fulöp, T
Furman, D
Gkrania-Klotsas, E
Goodrum, F
Grubeck-Loebenstein, B
Hurme, M
Kern, F
Lilleri, D
López-Botet, M
Maier, AB
Marandu, T
Marchant, A
Matheï, C
Moss, P
Muntasell, A
Remmerswaal, EBM
Riddell, N
Rothe, K
Sauce, D
Shin, E-C
Simanek, AM
Smithey, MJ
Söderberg-Nauclér, C
Solana, R
Thomas, PG
van Lier, R
Pawelec, G
Nikolich-Zugich, J
Date : July 2014
DOI : 10.1016/j.exger.2014.03.020
Copyright Disclaimer : © 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (
Uncontrolled Keywords : Immunosenescence, Cytomegalovirus infection, Immune homeostasis, Pathologies of aging, Virus-host interaction
Depositing User : Symplectic Elements
Date Deposited : 13 Mar 2017 14:42
Last Modified : 31 Oct 2017 19:11

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