The minor collagens in articular cartilage

Luo, YY, Sinkeviciute, D, He, Y, Karsdal, MA, Henrotin, Y, Mobasheri, Ali, Önnerfjord, P and Bay-Jensen, AC (2017) The minor collagens in articular cartilage Protein & Cell, 8 (8). pp. 560-572.

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Abstract

Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also fulfil specific biological functions. Genetic studies of these minor collagens have revealed that they are associated with multiple connective tissue diseases, especially degenerative joint disease. The progressive destruction of cartilage involves the degradation of matrix constituents including these minor collagens. The generation and release of fragmented molecules could generate novel biochemical markers with the capacity to monitor disease progression, facilitate drug development and add to the existing toolbox for in vitro studies, preclinical research and clinical trials.

Item Type:	Article
Subjects :	Veterinary Medicine
Divisions :	Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :	Name Email ORCID Luo, YY Sinkeviciute, D He, Y Karsdal, MA Henrotin, Y Mobasheri, Ali a.mobasheri@surrey.ac.uk Önnerfjord, P Bay-Jensen, AC
Date :	17 February 2017
DOI :	10.1007/s13238-017-0377-7
Copyright Disclaimer :	© The Author(s) 2017. This paper is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and production in any medium, provided the original Copyright-owner(s) and the source are credited, and is available at Springerlink.com and journal.hep.com.cn
Uncontrolled Keywords :	collagen, biomarker, arthritis
Related URLs :	Publisher
Depositing User :	Symplectic Elements
Date Deposited :	26 Jan 2017 14:28
Last Modified :	16 Jan 2019 17:11
URI:	http://epubs.surrey.ac.uk/id/eprint/813380

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