Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population
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Egan, Kieren, Campos Santos, H, Beijamini, F, Duarte, NE, Horimoto, ARVR, Taporoski, TP, Vallada, H, Negrão, AB, Krieger, JE, Pedrazzoli, M , Knutson, KL, Pereira, AC and von Schantz, Malcolm (2017) Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population Chronobiology International: the journal of biological and medical rhythm research, 34 (2). pp. 269-272.
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Abstract
Significant questions remain unanswered regarding the genetic versus environmental contributions to racial/ethnic differences in sleep and circadian rhythms. We addressed this question by investigating the association between diurnal preference, using the Morningness-Eveningness questionnaire (MEQ), and genetic ancestry within the Baependi Heart Study cohort, a highly admixed Brazilian population based in a rural town. Analysis was performed using measures of ancestry, using the Admixture program, and MEQ from 1,453 individuals. We found an association between the degree of Amerindian (but not European of African) ancestry and morningness, equating to 0.16 units for each additional percent of Amerindian ancestry, after adjustment for age, sex, education, and residential zone. To our knowledge, this is the first published report identifying an association between genetic ancestry and MEQ, and above all, the first one based on ancestral contributions within individuals living in the same community. This previously unknown ancestral dimension of diurnal preference suggests a stratification between racial/ethnic groups in an as yet unknown number of genetic polymorphisms.
| Item Type: | Article | ||||||||||||||||||||||||||||||||||||||||||
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| Subjects : | Biosciences and Medicine | ||||||||||||||||||||||||||||||||||||||||||
| Divisions : | Faculty of Health and Medical Sciences > School of Biosciences and Medicine | ||||||||||||||||||||||||||||||||||||||||||
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| Date : | 5 January 2017 | ||||||||||||||||||||||||||||||||||||||||||
| DOI : | 10.1080/07420528.2016.1265979 | ||||||||||||||||||||||||||||||||||||||||||
| Copyright Disclaimer : | This is an Accepted Manuscript of an article published by Taylor & Francis in Chronobiology International on 5 January 2017, available online: http://www.tandfonline.com/10.1080/07420528.2016.1265979 | ||||||||||||||||||||||||||||||||||||||||||
| Uncontrolled Keywords : | Admixture; American Native Continental Ancestry Group; Brazil; Chronotype; Circadian rhythm; Diurnal preference; Sleep homeostasis | ||||||||||||||||||||||||||||||||||||||||||
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| Depositing User : | Symplectic Elements | ||||||||||||||||||||||||||||||||||||||||||
| Date Deposited : | 24 Nov 2016 13:12 | ||||||||||||||||||||||||||||||||||||||||||
| Last Modified : | 16 Jan 2019 17:10 | ||||||||||||||||||||||||||||||||||||||||||
| URI: | http://epubs.surrey.ac.uk/id/eprint/812953 |
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