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The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial

Giannoulis, MG, Sonksen, PH, Umpleby, M, Breen, L, Pentecost, C, Whyte, M, McMillan, CV, Bradley, C and Martin, FC (2006) The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial The Journal of Clinical Endocrinology & Metabolism, 91 (2). pp. 477-484.

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CONTEXT: Declines in GH and testosterone (Te) secretion may contribute to the detrimental aging changes of elderly men. OBJECTIVE: To assess the effects of near-physiological GH with/without Te administration on lean body mass, total body fat, midthigh muscle cross-section area, muscle strength, aerobic capacity, condition-specific quality of life (Age-Related Hormone Deficiency-Dependent Quality of Life questionnaire), and generic health status (36-Item Short-Form Health Survey) of older men. DESIGN, SETTINGS, AND PARTICIPANTS: A 6-month, randomized, double-blind, placebo-controlled trial was performed on 80 healthy, community-dwelling, older men (age, 65-80 yr). INTERVENTIONS: Participants were randomized to receive 1) placebo GH or placebo Te, 2) recombinant human GH (rhGH) and placebo Te (GH), 3) Te and placebo rhGH (Te), or 4) rhGH and Te (GHTe). GH doses were titrated over 8 wk to produce IGF-I levels in the upper half of the age-specific reference range. A fixed dose of Te (5 mg) was given by transdermal patches. RESULTS: Lean body mass increased with GHTe (P = 0.008) and GH (P = 0.004), compared with placebo. Total body fat decreased with GHTe only (P = 0.02). Midthigh muscle (P = 0.006) and aerobic capacity (P < 0.001) increased only after GHTe. Muscle strength changes were variable; one of six measures significantly increased with GHTe. Significant treatment group by time interactions indicated an improved Age-Related Hormone Deficiency-Dependent Quality of Life questionnaire score (P = 0.007) in the GH and GHTe groups. Bodily pain increased with GH alone, as determined by the Short-Form Health Survey (P = 0.003). There were no major adverse effects. CONCLUSION: Coadministration of low dose GH with Te resulted in beneficial changes being observed more often than with either GH or Te alone.

Item Type: Article
Subjects : Nutrition
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :
Giannoulis, MG
Sonksen, PH
Umpleby, M
Breen, L
Pentecost, C
Whyte, M
McMillan, CV
Bradley, C
Martin, FC
Date : February 2006
DOI : 10.1210/jc.2005-0957
Uncontrolled Keywords : Aged, Aged, 80 and over, Body Composition, Double-Blind Method, Hand Strength, Human Growth Hormone, Humans, Insulin-Like Growth Factor I, Male, Muscle, Skeletal, Physical Fitness, Quality of Life, Surveys and Questionnaires, Testosterone
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 18 Oct 2016 14:41
Last Modified : 31 Oct 2017 18:48

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