Ovicidal efficacy of fenbendazole after treatment of horses naturally infected with cyathostomins

Proudman, CJ (2016) Ovicidal efficacy of fenbendazole after treatment of horses naturally infected with cyathostomins Veterinary Parasitology, 227. pp. 151-156.

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Abstract

The ovicidal activity of benzimidazole (BZ) anthelmintics is unique and not seen in other drug classes. Such ovicidal efficacy is not widely reported for equine cyathostomins, nor has this activity been tested in the face of BZ resistance. Although the product label states that fenbendazole is for use against BZ-susceptible cyathostomins, susceptibility testing is rarely performed. In this field-based study, the ovicidal efficacy of fenbendazole in horses (n = 39) harbouring BZ-resistant cyathostomins was compared when dosed at 7.5 mg/kg body weight (BW) orally, as a single dose per os (n = 21) or daily for five consecutive days in feed (n = 18). Suppression of egg hatch rate was observed in the single and five- day treatment groups; a significant difference between pre- and post-treatment egg hatch rates (P < 0.05) was observed for three days after treatment with a single dose of fenbendazole (on premises with BZ-resistant cyathostomins), and for three days after treatment for five consecutive days with fenbendazole (on premises with BZ-resistant cyathostomins). Post treatment numbers of eggs and larvae remained significantly lower (P < 0.05) than pre-treatment levels to the end of the trial. We conclude that in the face of BZ-resistant cyathostomins the ovicidal effect of fenbendazole persist for three days after both a single oral dose of 7.5 mg/kg per os and after treatment orally for five consecutive daily doses at 7.5 mg/kg in feed.

Item Type:	Article
Subjects :	Veterinary Medicine
Divisions :	Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :	Name Email ORCID Proudman, CJ
Date :	3 August 2016
Funders :	MSD Animal Health
DOI :	10.1016/j.vetpar.2016.08.004
Grant Title :	Ovicidal efficacy of fenbendazole in horses
Copyright Disclaimer :	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords :	benzimidazole, cyathostomin, efficacy, egg hatch assay, ovicidal
Depositing User :	Symplectic Elements
Date Deposited :	01 Nov 2016 14:22
Last Modified :	11 Dec 2018 11:22
URI:	http://epubs.surrey.ac.uk/id/eprint/812459

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