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Generation of 3D synthetic breast tissue

Elangovan, P, Dance, DR, Young, KC and Wells, K (2016) Generation of 3D synthetic breast tissue In: SPIE Medical Imaging, 2016-02-22 - 2016-03-03, San Diego.

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Virtual clinical trials are an emergent approach for the rapid evaluation and comparison of various breast imaging technologies and techniques using computer-based modeling tools. A fundamental requirement of this approach for mammography is the use of realistic looking breast anatomy in the studies to produce clinically relevant results. In this work, a biologically inspired approach has been used to simulate realistic synthetic breast phantom blocks for use in virtual clinical trials. A variety of high and low frequency features (including Cooper’s ligaments, blood vessels and glandular tissue) have been extracted from clinical digital breast tomosynthesis images and used to simulate synthetic breast blocks. The appearance of the phantom blocks was validated by presenting a selection of simulated 2D and DBT images interleaved with real images to a team of experienced readers for rating using an ROC paradigm. The average areas under the curve for 2D and DBT images were 0.53±.04 and 0.55±.07 respectively; errors are the standard errors of the mean. The values indicate that the observers had difficulty in differentiating the real images from simulated images. The statistical properties of simulated images of the phantom blocks were evaluated by means of power spectrum analysis. The power spectrum curves for real and simulated images closely match and overlap indicating good agreement.

Item Type: Conference or Workshop Item (Conference Paper)
Subjects : Electronic Engineering
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
Elangovan, P
Dance, DR
Young, KC
Wells, K
Date : 22 March 2016
Funders : CR-UK
DOI : 10.1117/12.2216225
Grant Title : Optimam 2
Copyright Disclaimer : Elangovan et al, "Generation of 3D synthetic breast tissue SPIE Medial Imaging 2016," Despina Kontos; Thomas G. Flohr, Editor(s), Proc. SPIE Proc. SPIE 9783, Medical Imaging 2016: Physics of Medical Imaging, 978308 (22 March 2016) Copyright 2016 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Contributors :
Kontos, D
Flohr, TG
Uncontrolled Keywords : mammography, tomosynthesis, virtual clinical trial, breast tissue, simulation, validation, ROC, Power spectrum, fractal
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 13 Sep 2016 09:47
Last Modified : 11 Dec 2018 11:22

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