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Insulin-like growth factor-II: its role in metabolic and endocrine disease.

Livingstone, C and Borai, A (2014) Insulin-like growth factor-II: its role in metabolic and endocrine disease. Clinical Endocrinology, 80 (6). pp. 773-781.

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Insulin-like growth factor-II (IGF-II) is a widely expressed 7·5 kDa mitogenic peptide hormone. Although it is abundant in serum, understanding of its physiological role is limited compared with that of IGF-I. IGF-II regulates foetal development and differentiation, but its role in adults is less well understood. Evidence suggests roles in a number of tissues including skeletal muscle, adipose tissue, bone and ovary. Altered IGF-II expression has been observed in metabolic conditions, notably obesity, diabetes and the polycystic ovary syndrome. This article summarizes what is known about the actions of IGF-II and its dysregulation in metabolic and endocrine diseases. The possible causes and consequences of dysregulation are discussed along with the implications for diagnostic tests and future research.

Item Type: Article
Subjects : Medical Science
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Livingstone, C
Borai, A
Date : June 2014
DOI : 10.1111/cen.12446
Copyright Disclaimer : © 2014 John Wiley & Sons Ltd
Uncontrolled Keywords : Animals, Bone Diseases, Metabolic, Diabetes Mellitus, Endocrine System, Endocrine System Diseases, Female, Gene Expression Regulation, Growth Disorders, Humans, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Male, Metabolic Diseases, Mice, Obesity, Polycystic Ovary Syndrome
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 01 Sep 2016 07:47
Last Modified : 31 Oct 2017 18:39

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