Distribution and load of elephant endotheliotropic herpesviruses in tissues from associated fatalities of Asian elephants
Seilern-Moy, Katharina, Darpel, Karin, Steinbach, Falko and Dastjerdi, A (2016) Distribution and load of elephant endotheliotropic herpesviruses in tissues from associated fatalities of Asian elephants Virus Research, 220. pp. 91-96.
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Abstract
Elephant Endotheliotropic Herpesviruses (EEHVs) are the cause of a highly fatal haemorrhagic disease in elephants primarily affecting young Asian elephants (Elephas maximus) in both captivity and in the wild. The viruses have emerged as a significant threat to Asian elephant conservation, critically affecting overall sustainability of their population. So far insight into the pathogenesis of EEHV infections has been restricted to examination of EEHV-infected tissues. However, little is known about distribution and burden of the viruses within the organs of fatal cases, crucial elements in the understanding of the virus pathogenesis. This study was therefore undertaken to assess the extent of organ and cell involvement in fatal cases of EEHV-1A, 1B and 5 using a quantitative real-time PCR. EEHV-1 and 5 DNA were detectable in all the tissues examined, albeit with substantial differences in the viral DNA load. The highest EEHV-1A DNA load was observed in the liver, followed by the heart, thymus and tongue. EEHV-1B and 5 showed the highest DNA load in the heart, followed by tongue and liver. This study provides new insights into EEHV pathogenicity and has implications in choice of sample type for disease investigation and virus isolation.
Item Type: | Article | |||||||||||||||
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Subjects : | Veterinary Medicine | |||||||||||||||
Divisions : | Faculty of Health and Medical Sciences > School of Veterinary Medicine | |||||||||||||||
Authors : |
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Date : | 19 April 2016 | |||||||||||||||
DOI : | 10.1016/j.virusres.2016.04.012 | |||||||||||||||
Copyright Disclaimer : | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||
Depositing User : | Symplectic Elements | |||||||||||||||
Date Deposited : | 31 Aug 2016 17:41 | |||||||||||||||
Last Modified : | 16 Jan 2019 17:07 | |||||||||||||||
URI: | http://epubs.surrey.ac.uk/id/eprint/811937 |
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