The ageing human B cell repertoire: A failure of selection?

Dunn-Walters, D (2015) The ageing human B cell repertoire: A failure of selection? Clinical & Experimental Immunology, 183 (1). pp. 50-56.

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Abstract

B cells undergo a number of different developmental stages, from initial formation of their B cell receptor (BCR) genes to differentiation into antibody-secreting plasma cells. Because the BCR is vital in these differentiation steps, autoreactive and exogenous antigen binding to the BCR exert critical selection pressures to shape the B cell repertoire. Older people are more prone to infectious disease, less able to respond well to vaccination and more likely to have autoreactive antibodies. Here we review evidence of changes in B cell repertoires in older people, which may be a reflection of age-related changes in B cell selection processes.

Item Type:	Article
Subjects :	Biosciences and Medicine
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :	Name Email ORCID Dunn-Walters, D
Date :	22 December 2015
DOI :	10.1111/cei.12700
Copyright Disclaimer :	This is the peer reviewed version of the following article: Dunn-Walters, D. K. (2016), The ageing human B cell repertoire: a failure of selection?. Clinical & Experimental Immunology, 183: 50–56. doi: 10.1111/cei.12700, which has been published in final form at http://dx.doi.org/10.1111/cei.12700. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords :	ageing;antibodies;B cell;repertoire;selection
Depositing User :	Symplectic Elements
Date Deposited :	06 Jul 2016 13:17
Last Modified :	22 Dec 2016 02:08
URI:	http://epubs.surrey.ac.uk/id/eprint/811125

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