Schistosoma mansoni infection in preschool-aged children: development of immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like proteins.

Pinot de Moira, A, Sousa-Figueiredo, JC, Jones, FM, Fitzsimmons, CM, Betson, M, Kabatereine, NB, Stothard, JR and Dunne, DW (2013) Schistosoma mansoni infection in preschool-aged children: development of immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like proteins. J Infect Dis, 207 (2). pp. 362-366.

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Abstract

Specific immunoglobulin E (IgE) responses are upregulated during chronic schistosome infection and during allergy. These responses are tightly regulated during schistosomiasis. We have previously shown that IgE regulation depends on the extent and length of exposure to individual parasite allergen-like proteins. Here we compare the development of IgE and immunoglobulin G4 (IgG(4)) responses to the differentially expressed allergen-like proteins SmTAL1 and SmTAL2 among preschool-aged children from 2 villages with different levels of Schistosoma mansoni transmission. We found a lack of SmTAL1 responsiveness among all children, but evidence for IgG(4)-dependent IgE-SmTAL2 desensitization in both villages, occurring earlier among children from the village where the level of transmission was greater. Findings provide insights into the development and regulation of allergic-type immune responses.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences
Authors :	Name Email ORCID Pinot de Moira, A Sousa-Figueiredo, JC Jones, FM Fitzsimmons, CM Betson, M Kabatereine, NB Stothard, JR Dunne, DW
Date :	15 January 2013
DOI :	10.1093/infdis/jis676
Uncontrolled Keywords :	Adult, Allergens, Animals, Child, Preschool, Female, Helminth Proteins, Humans, Immunoglobulin E, Immunoglobulin G, Infant, Schistosoma mansoni, Schistosomiasis mansoni, Uganda
Related URLs :	Author
Additional Information :	© The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Depositing User :	Symplectic Elements
Date Deposited :	11 Aug 2015 14:43
Last Modified :	31 Oct 2017 17:33
URI:	http://epubs.surrey.ac.uk/id/eprint/808131

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