Radiosensitization of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays.
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Barazzuol, L, Jeynes, JC, Merchant, MJ, Wéra, AC, Barry, MA, Kirkby, KJ and Suzuki, M (2015) Radiosensitization of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays. Int J Radiat Biol, 91 (1). pp. 90-98.
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Official URL: http://dx.doi.org/10.3109/09553002.2014.946111
Abstract
Prognosis for patients with glioblastoma (GBM) remains poor, and new treatments are needed. Here we used a combination of two novel treatment modalities: Carbon ions and a histone deacetylase inhibitor (HDACi). We compared these to conventional X-rays, measuring the increased effectiveness of carbon ions as well as radiosensitization using HDACi.
| Item Type: | Article | ||||||||||||||||||||||||
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| Divisions : | Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute > Ion Beam Centre | ||||||||||||||||||||||||
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| Date : | January 2015 | ||||||||||||||||||||||||
| DOI : | 10.3109/09553002.2014.946111 | ||||||||||||||||||||||||
| Uncontrolled Keywords : | DNA double-strand break repair, High-LET, chromatin decondensation, clonogenic assay, Carbon, Cell Line, Tumor, DNA, DNA Repair, Glioblastoma, Histone Deacetylase Inhibitors, Histones, Humans, Hydroxamic Acids, Radiation-Sensitizing Agents, X-Rays | ||||||||||||||||||||||||
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| Additional Information : | This is an electronic version of an article published in International Journal of Radiation Biology, Ahead of Print : Pages 1-19 Radiosensitisation of glioblastoma cells using a histone deacetylase inhibitor (SAHA) comparing carbon ions with X-rays. L. Barazzuol , J.C.G Jeynes , M.J. Merchant , A-C. Wéra , M. Barry , K.J. Kirkby , M. Suzuki (doi:10.3109/09553002.2014.946111). Int J Radiat Biol is available online at http://informahealthcare.com/journal/rab | ||||||||||||||||||||||||
| Depositing User : | Symplectic Elements | ||||||||||||||||||||||||
| Date Deposited : | 09 Sep 2014 11:22 | ||||||||||||||||||||||||
| Last Modified : | 21 Jul 2015 01:08 | ||||||||||||||||||||||||
| URI: | http://epubs.surrey.ac.uk/id/eprint/805893 |
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