University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae)

Mulholland, Dulcie, Mwangi, EM, Dlova, NC, Plant, N, Crouch, NR and Coombes, PH (2013) Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae) JOURNAL OF ETHNOPHARMACOLOGY, 149 (2). pp. 570-575.

Text (licence)

Download (33kB)

Download (326kB)


Ethnopharmacological relevance The stem bark of Garcinia livingstonei is used traditionally as a skin lightening agent. Aim of the study To isolate and identify compounds responsible for the observed skin lightening activity of Garcinia livingstonei and to evaluate their cytotoxicity. Materials and methods Constituents of the stem bark and fruits of Garcinia livingstonei were isolated using chromatographic techniques and structures were determined using 1D and 2D NMR and MS analysis. MeWo cells were used to evaluate the cytotoxicity and impact on melanin levels of extracts and compounds isolated, in vitro. Results Twelve known compounds, morelloflavone (1), morelloflavone-7″-sulphate (2), guttiferone A (3), sargaol (4), isojacareubin (5), 6-deoxyisojacareubin (6) and in addition to the common triterpenoids, betulin, betulin aldehyde, lupeol, lupenone, euphol and stigmasterol were isolated in this investigation. Morelloflavone, morelloflavone-7″-sulphate and sargaol, were found to be considerably less cytotoxic and more effective as skin lightening agents than hydroquinone. Conclusions A range of compounds was isolated from the stem bark and fruit of Garcinia livingstonei. Although the bark extract contained the cytotoxic guttiferone A, it was found to be less toxic than hydroquinone, and morelloflavone, the 7″-sulphate derivative and sargaol show potential for development as depigmentation/skin lightening agents.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
Mwangi, EM
Dlova, NC
Plant, N
Crouch, NR
Coombes, PH
Date : 1 September 2013
DOI : 10.1016/j.jep.2013.07.023
Copyright Disclaimer : © 2013 Elsevier Ireland Ltd.
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Plant Sciences, Chemistry, Medicinal, Integrative & Complementary Medicine, Pharmacology & Pharmacy, CHEMISTRY, MEDICINAL, INTEGRATIVE & COMPLEMENTARY MEDICINE, PHARMACOLOGY & PHARMACY, PLANT SCIENCES, Garcinia livingstonei, Clusiaceae, Melanin production inhibitor, MeWo cells, Skin lightening agents, SKIN-LIGHTENING COSMETICS, SYMPHONIA-GLOBULIFERA, NATURAL-PRODUCTS, TYROSINASE INHIBITORS, EXOGENOUS OCHRONOSIS, TRADITIONAL MEDICINE, HYPERICUM-JAPONICUM, RHEEDIA-GARDNERIANA, PHENOLIC-COMPOUNDS, IN-VITRO
Related URLs :
Additional Information : NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Ethnopharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Ethnopharmacology, July 2013, DOI 10.1016/j.jep.2013.07.023.
Depositing User : Symplectic Elements
Date Deposited : 28 Aug 2013 13:19
Last Modified : 16 Jan 2019 16:45

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800