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Complex microstructured 3D surfaces using chitosan biopolymer.

Fernandez, JG, Mills, CA and Samitier, J (2009) Complex microstructured 3D surfaces using chitosan biopolymer. Small, 5 (5). pp. 614-620.

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A technique for producing micrometer-scale structures over large, nonplanar chitosan surfaces is described. The technique makes use of the rheological characteristics (deformability) of the chitosan to create freestanding, three-dimensional scaffolds with controlled shapes, incorporating defined microtopography. The results of an investigation into the technical limits of molding different combinations of shapes and microtopographies are presented, highlighting the versatility of the technique when used irrespectively with inorganic or delicate organic moulds. The final, replicated scaffolds presented here are patterned with arrays of one-micrometer-tall microstructures over large areas. Structural integrity is characterized by the measurement of structural degradation. Human umbilical vein endothelial cells cultured on a tubular scaffold show that early cell growth is conditioned by the microtopography and indicate possible uses for the structures in biomedical applications. For those applications requiring improved chemical and mechanical resistance, the structures can be replicated in poly(dimethyl siloxane).

Item Type: Article
Divisions : Surrey research (other units)
Authors : Fernandez, JG, Mills, CA and Samitier, J
Date : March 2009
DOI : 10.1002/smll.200800907
Uncontrolled Keywords : Biocompatible Materials, Cell Adhesion, Cell Culture Techniques, Cell Proliferation, Cells, Cultured, Chitosan, Crystallization, Endothelial Cells, Humans, Materials Testing, Nanostructures, Nanotechnology, Particle Size, Surface Properties, Tissue Engineering
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 14:12
Last Modified : 24 Jan 2020 11:52

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