The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer.
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Coley, HM, Safuwan, NA, Chivers, P, Papacharalbous, E, Giannopoulos, T, Butler-Manuel, S, Madhuri, K, Lovell, DP and Crook, T (2012) The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer. Br J Cancer, 106 (3). pp. 482-489.
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Official URL: http://dx.doi.org/10.1038/bjc.2011.566
Abstract
Carboplatin remains a first-line agent in the management of epithelial ovarian cancer (EOC). Unfortunately, platinum-resistant disease ultimately occurs in most patients. Using a novel EOC cell line with acquired resistance to carboplatin: PEO1CarbR, genome-wide micro-array profiling identified the cyclin-dependent kinase inhibitor p57(Kip2) as specifically downregulated in carboplatin resistance. Presently, we describe confirmation of these preliminary data with a variety of approaches.
| Item Type: | Article | ||||||||||||||||||||||||||||||
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| Divisions : | Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences | ||||||||||||||||||||||||||||||
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| Date : | 31 January 2012 | ||||||||||||||||||||||||||||||
| DOI : | 10.1038/bjc.2011.566 | ||||||||||||||||||||||||||||||
| Uncontrolled Keywords : | Antineoplastic Agents, Carboplatin, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p27, DNA Methylation, Dose-Response Relationship, Drug, Down-Regulation, Drug Resistance, Neoplasm, Epigenesis, Genetic, Female, Humans, Ovarian Neoplasms, Purines | ||||||||||||||||||||||||||||||
| Additional Information : | British Journal of Cancer (2012) 106, 482 – 489 & 2012 Cancer Research UK All rights reserved 0007 – 0920/12 | ||||||||||||||||||||||||||||||
| Depositing User : | Symplectic Elements | ||||||||||||||||||||||||||||||
| Date Deposited : | 29 Jun 2012 09:19 | ||||||||||||||||||||||||||||||
| Last Modified : | 31 Oct 2017 14:39 | ||||||||||||||||||||||||||||||
| URI: | http://epubs.surrey.ac.uk/id/eprint/711605 |
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