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Adipose circadian rhythms: Translating cellular and animal studies to human physiology.

Johnston, Jonathan (2012) Adipose circadian rhythms: Translating cellular and animal studies to human physiology. Molecular and Cellular Endocrinology, 349 (1). pp. 45-50.

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Emerging links between circadian rhythms and metabolism promise much for the understanding of metabolic physiology and pathophysiology, in which white adipose tissue (WAT) plays a prominent role. Many WAT endocrine molecules, termed adipokines, display rhythmic plasma concentration. Moreover, similar to most other tissues, WAT exhibits widespread 24-h variation in gene expression, with approximately 20% of the murine adipose transcriptome estimated to undergo daily variation. A major limitation to human chronobiology research is the availability of physiologically defined peripheral tissues. To date most analyses of in vivo human peripheral clocks has been limited to blood leucocytes. However, subcutaneous adipose tissue represents a novel opportunity to study peripheral molecular rhythms that are of clearly defined metabolic relevance. This review summarises basic concepts of circadian and metabolic physiology before then comparing alternative protocols used to analyse the rhythmic properties of human adipose tissue.

Item Type: Article
Subjects : Medical Sciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
Date : 5 February 2012
DOI : 10.1016/j.mce.2011.05.008
Copyright Disclaimer : © 2012. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Depositing User : Symplectic Elements
Date Deposited : 22 Jul 2011 10:19
Last Modified : 16 Jan 2019 16:25

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