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T-type Ca2+ channels in non-vascular smooth muscles

Fry, CH, Sui, G and Wu, C (2006) T-type Ca2+ channels in non-vascular smooth muscles CELL CALCIUM, 40 (2). pp. 231-239.

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T-type Ca2+ current has been recorded in smooth muscle myocytes, and associated interstitial cells, from smooth muscle cells isolated from the gastro-intestinal tract, urinary bladder, urethra, prostate gland, myometrium, vas deferens, lymphatic vessels and airways smooth muscle. By contrast, current through such channels has not been recorded from other tissues, such as the ureter. Whilst the properties of this Ca2+ current are similar in most of these cells, with respect to their voltage-dependence, ion selectivity and response to channel modulators, some differences have been recorded, most notably in the gastro-intestinal tract, and may demand a reappraisal of how a T-type Ca2+ current is characterised. The functions of such a current in different tissues remains uncertain. In most of smooth muscles discussed in this review, it is hypothesised that it underlies rhythmic or spontaneous electrical activity, especially in concert with other current-carrying systems, such as Ca2+-activated outward currents. Of equal interest is that the T-type Ca2+ channel may be a target for agents that modulate tissue function, especially in pathological conditions, or are the site of secondary effects of agents used in clinical medicine. For example, T-type Ca2+ channel modulators have been proposed to reduce overactive muscular activity in the gastro-intestinal or urinary tract, or function as tocolytic agents: and the action of volatile anaesthetics on them in airways smooth muscle requires consideration in their overall action.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Clinical and Experimental Medicine
Authors : Fry, CH, Sui, G and Wu, C
Date : August 2006
DOI : 10.1016/j.ceca.2006.04.027
Uncontrolled Keywords : T-type Ca2+ channel, smooth muscle, bladder, urinary tract, gastro-intestinal tract, myometrium, airways smooth muscle, GUINEA-PIG URETER, DECIDUAL STROMAL CELLS, MOUSE SMALL-INTESTINE, CALCIUM-CHANNEL, INTERSTITIAL-CELLS, VAS-DEFERENS, ACTION-POTENTIALS, IONIC CURRENTS, CANINE COLON, SPONTANEOUS EXCITATION
Additional Information : NOTICE: this is the author’s version of a work that was accepted for publication in Cell Calcium. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cell Calcium, 40(2), August 2006, DOI 10.1016/j.ceca.2006.04.027.
Depositing User : Symplectic Elements
Date Deposited : 23 Mar 2012 12:37
Last Modified : 06 Jul 2019 05:10

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