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Digital Autoradiography using CCD and CMOS Imaging Technology

Cabello, J, Bailey, A, Kitchen, I, Clark, A, Crooks, J, Halsall, R, Key-Charriere, M, Martin, S, Prydderch, M, Turchetta, R and Wells, K (2006) Digital Autoradiography using CCD and CMOS Imaging Technology 2006 IEEE Nuclear Science Symposium Conference Record, 4. pp. 2607-2612.

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CCD and CMOS imaging technologies can be applied to thin tissue Autoradiography as potential imaging alternatives to using conventional film. In this work, we compare two particular devices; a CCD operating in slow scan mode and a CMOS-based Active Pixel sensor, operating at near video rates. Both imaging sensors have been operated at room temperature with images produced from calibrated microscales and radiolabelled tissue samples. We also compare these digital imaging technologies with the use of conventional film. We show first comparative results obtained with 14C calibrated microscales and 35S radiolabelled tissue sections. We also present first results of 3H images produced under direct irradiation of a CCD sensor operating at room temperature. Compared to film, silicon-based imaging technologies exhibit enhanced sensitivity, dynamic range and linearity.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
Clark, A
Crooks, J
Halsall, R
Key-Charriere, M
Martin, S
Prydderch, M
Turchetta, R
Date : 2006
DOI : 10.1109/NSSMIC.2006.354442
Related URLs :
Additional Information : ©2006 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
Depositing User : Users 8 not found.
Date Deposited : 03 Nov 2010 09:38
Last Modified : 06 Jul 2019 05:07

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