Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins.

Scherrer, T, Femmer, C, Schiess, R, Aebersold, R and Gerber, AP (2011) Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Genome Biology, 12 (1).

Preview	Text Scherrer et al. 2011 Genom Biol.pdf Available under License : See the attached licence file. Download (1MB)
Preview	Text (licence) SRI_deposit_agreement.pdf Download (33kB)

Abstract

Glucose inhibition of gluconeogenic growth suppressor 2 protein (Gis2p) and zinc-finger protein 9 (ZNF9) are conserved yeast and human zinc-finger proteins. The function of yeast Gis2p is unknown, but human ZNF9 has been reported to bind nucleic acids, and mutations in the ZNF9 gene cause the neuromuscular disease myotonic dystrophy type 2. To explore the impact of these proteins on RNA regulation, we undertook a systematic analysis of the RNA targets and of the global implications for gene expression.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Microbial and Cellular Sciences
Authors :	Name Email ORCID Scherrer, T Femmer, C Schiess, R Aebersold, R Gerber, AP
Date :	2011
DOI :	10.1186/gb-2011-12-1-r3
Uncontrolled Keywords :	Amino Acid Sequence, Cell Proliferation, Cell Size, Codon, Initiator, Conserved Sequence, Gene Expression Profiling, Gene Expression Regulation, Humans, Molecular Sequence Data, Open Reading Frames, Phenotype, Proteome, RNA, Messenger, RNA-Binding Proteins, Regulon, Repetitive Sequences, Nucleic Acid, Saccharomyces cerevisiae Proteins, Sequence Alignment, Sequence Homology, Amino Acid, Transcriptome, Zinc Fingers
Additional Information :	Subject to license at: http://www.biomedcentral.com/about/license
Depositing User :	Symplectic Elements
Date Deposited :	04 May 2012 11:29
Last Modified :	31 Oct 2017 14:26
URI:	http://epubs.surrey.ac.uk/id/eprint/211742

Actions (login required)

View Item

Downloads